Champions Liverpool will kick off the defence of their first Premier League title against promoted Leeds United.
The two sides will clash at Anfield for the first time since February 2004 on the opening day of the 2020/21 season, after the Whites won the Championship to seal their return to the top-flight.
The Premier League season will start on Saturday September 12, while the final day of the new season is scheduled to take place on May 23, 2021.
The campaign was initially planned to start on August 8 but was forced to be delayed due to the coronavirus pandemic.
Elsewhere on the opening day, there is a London derby between newly-promoted Fulham and Arsenal, while the first Monday fixtures of the season see Brighton host Chelsea and Wolves visit Sheffield United.
Finally on the opening weekend, Crystal Palace meet Southampton, Tottenham take on Everton and Newcastle go to West Ham.
Manchester United and Man City have been given the opening day of the new season off due to their exertions in the 2019/20 European competitions, so their first matches will take place on September 19.
That also means their scheduled opponents, Burnley and Aston Villa, will not kick off their campaigns until September 19.
Premier League 2020/21 key information
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Start date: September 12, 2020
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Proposed final day: May 23, 2021
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Reigning champions: Liverpool
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Newly-promoted teams: Leeds United, West Bromwich Albion, Fulham
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Transfer window dates: July 27 to October 5
The 2019/20 Premier League season was undoubtedly the strangest campaign in history, but it was still as intriguing as ever with Liverpool steamrolling to their first top-flight crown in 30 years.
From the introduction of VAR to the campaign’s unprecedented disruption due to the coronavirus pandemic, the season had it all and fans now only have one month to wait for the return of top-flight football.
Premier League 2020/21 opening day fixtures
Crystal Palace vs Southampton (Saturday, September 12 – 3pm)
Fulham vs Arsenal (Saturday, September 12 – 3pm)
Liverpool vs Leeds United (Saturday, September 12 – 3pm)
Tottenham Hotspur vs Everton (Saturday, September 12 – 3pm)
West Bromwich Albion vs Leicester City (Saturday, September 12 – 3pm)
West Ham United vs Newcastle United (Saturday, September 12 – 3pm)
Brighton and Hove Albion vs Chelsea (Monday, September 14 – 8pm)
Sheffield United vs Wolverhampton Wanderers (Monday, September 14 – 8pm)
Burnley vs Manchester United (postponed to later date)
Manchester City vs Aston Villa (postponed to later date)